Introducing Arthrosamid®
Arthrosamid® is a non-biodegradable injectable polyacrylamide hydrogel (2.5% iPAAG) implant consisting of 2.5% cross-linked polyacrylamide and 97.5% water. It is administered via a simple, one-step procedure performed under local anaesthesia by a qualified physician, such as an orthopaedic surgeon or rheumatologist1 — ensuring you’re in and out of the clinic the same day. Arthrosamid® is proven to maintain a significant, long-lasting reduction in knee OA pain— even five years post-treatment.
How does Arthrosamid® work?
Arthrosamid® is the first and only permanent injectable implant that integrates with the knee’s synovial tissue, forming a scaffold that softens and increases tissue elasticity. This leads to decreased joint stiffness, reduced pain, and improved knee function.
Proven Results
- Over 20 years of research and development.
- Safe and effective, for its intended use, even five years post-treatment.
- Around 1,200,000 syringes of 2.5% iPAAG have been made for human use.
Arthrosamid® FAQ
Who could benefit from Arthrosamid® Injections?
Arthrosamid® is an approved treatment to reduce the pain and stiffness of knee osteoarthritis. It cushions and lubricates the knee joint, improving your movement and reducing discomfort. If your knee osteoarthritis is causing pain, restricting your mobility and reducing your quality of life, this injection can provide relief without the need for surgery.
What happens during an Arthrosamid® injection?
Your consultant will refer you for an Arthrosamid® injection. It is a minimally invasive procedure, performed under local anaesthetic, so you will not ordinarily need to stay in hospital overnight.
What are the benefits of Arthrosamid® Injections?
They provide safe and sustained relief from the pain of knee osteoarthritis, improving movement and boosting your quality of life.
The injection is designed to not degrade in the body, giving long-lasting pain relief. In clinical trials, patients noticed significantly reduced pain symptoms four weeks after injection, and this was maintained when they were followed up after three years.
Other injectable treatments, including steroid injections, are effective for a much shorter time. Arthrosamid® is active for longer, and you can receive repeated injections without endangering the health and structure of your knee joint.
What are the risks of Arthrosamid® Injections?
All joint injections carry risks however Arthrosamid® is generally very safe; there were no serious side effects in clinical trials. The risks of these injections include:
- Pain following the injection
- Swelling around the injection site
- A small risk of allergy to the medication
- A small risk of joint infection
It is important to bear in mind that there is no cure for osteoarthritis, but treatment with Arthrosamid® may reduce or relieve your pain. You should also bear in mind that your osteoarthritis may not improve, and in some cases, it may get worse.





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